Transplant Outcomes in Bone Marrow Failure Syndromes and Hemoglobinopathies

被引：24
|
作者：
MacMillan, Margaret L. [1 ]
Walters, Mark C. [2 ]
Gluckman, Eliane [3 ,4 ]
机构：
[1] Univ Minnesota, Sch Med, Div Pediat Hematol Oncol & Blood & Marrow Transpl, Minneapolis, MN 55455 USA
[2] Childrens Hosp & Res Ctr, Oakland, CA USA
[3] Hosp St Louis, Paris, France
[4] Univ Paris 07, Paris, France
来源：
SEMINARS IN HEMATOLOGY | 2010年 / 47卷 / 01期
关键词：
STEM-CELL TRANSPLANTATION; CORD-BLOOD TRANSPLANTATION; TOTAL-BODY IRRADIATION; TRANSFUSION-DEPENDENT THALASSEMIA; ACQUIRED APLASTIC-ANEMIA; MATCHED RELATED DONOR; FANCONI-ANEMIA; CONDITIONING REGIMEN; ALTERNATIVE DONORS; BETA-THALASSEMIA;
D O I：
10.1053/j.seminhematol.2009.10.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potential cure for most bone marrow (BM) failure syndromes and hemoglobinopathies. Over the past decade, umbilical cord blood (UCB) has been used more frequently as a stem cell source in patients who lack a suitable BM donor. Although graft failure remains a significant problem, UCB transplantation (UCBT) using the optimal conditioning regimen can be a salvage treatment for patients without a suitable BM donor and warrants evaluation in further prospective studies. Semin Hematol 47:37-45. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：37 / 45
页数：9
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