This study aimed to identify programmatic vulnerability to STDs/HIV/AIDS in primary health centers (PHCs). This is a descriptive and quantitative study carried out in the city of Sao Paulo. An online survey was applied (FormSUS platform), involving administrators from 442 PHCs in the city, with responses received from 328 of them (74.2%), of which 53.6% were nurses. Attention was raised in relation to programmatic vulnerability in the PHCs regarding certain items of infrastructure, prevention, treatment, prenatal care and integration among services on STDs/HIV/AIDS care. It was concluded that in order to reach comprehensiveness of actions for HIV/AIDS in primary health care, it is necessary to consider programmatic vulnerability, in addition to more investment and reorganization of services in a dialogue with the stakeholders (users, multidisciplinary teams, and managers, among others).