DTBP-promoted site-selective α-alkoxyl C-H functionalization of alkyl esters: synthesis of 2-alkyl ester substituted chromanones

被引：4
|
作者：
Yu, Jin-Tao [1 ]
Li, Yiting [1 ]
Chen, Rongzhen [1 ]
Yang, Zixian [1 ]
Pan, Changduo [1 ,2 ]
机构：
[1] Changzhou Univ, Jiangsu Key Lab Adv Catalyt Mat & Technol, Sch Petrochem Engn, Changzhou 213164, Jiangsu, Peoples R China
[2] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Jiangsu, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 20期
基金：
中国国家自然科学基金;
关键词：
We thank the National Natural Science Foundation of China (21672028) and the Qing Lan Project of Jiangsu Province and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology (BM2012110) for financial support;
D O I：
10.1039/d1ob00605c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct C-H functionalization of ethyl acetates was developed, delivering a variety of 1-(4-oxochroman-2-yl)ethyl acetate derivatives by reacting with chromones. This reaction has a wide substrate scope with excellent site-selective C-H activation at the inactive alpha-hydrogen of the alkoxyl group instead of the alpha-hydrogen of the carbonyl group under radical conditions. Compared with other protocols for the alpha-alkoxyl C-H functionalization of alkyl esters, a distinguishing feature of this reaction is that no metal catalyst was required, with DTBP as the sole oxidant.
引用
收藏
页码：4520 / 4528
页数：9
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