INHERITED EPIDERMOLYSIS BULLOSA

Inherited epidermolysis bullosa (EB) is characterized by a lack of anchoring filaments that facilitate adhesion of the epidermal and dermal layers of the skin. This results in significant blister or sore formation in response to minor mechanical trauma, which has a detrimental impact on patient quality of life. While the standard of care tends to focus on wound healing/hygiene, a further understanding of the molecular and genetic events underlying skin separation has led to the identification of alternative treatment methods that may provide novel solutions for EB. This review focuses on the more up-to-date publications emerging from EB research, including advances in gene therapy, protein therapy, cell therapy, tissue engineering, the use of natural products and pharmacotherapeutics, highlighting ongoing clinical trials in the field.