p38 mitogen-activated protein kinases on the body surface -: A function for p38δ

被引：84
|
作者：
Eckert, RL
Efimova, T
Balasubramanian, S
Crish, JF
Bone, F
Dashti, S
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Phys & Biophys, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Dept Reprod Biol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Sch Med, Dept Oncol, Cleveland, OH 44106 USA
[5] Case Western Reserve Univ, Sch Med, Dept Dermatol, Cleveland, OH 44106 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2003年 / 120卷 / 05期
关键词：
apoptosis; ERK; involucrin; keratinocyte differentiation; MAPK; p38; delta; gamma; signal transduction;
D O I：
10.1046/j.1523-1747.2003.12120.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The p38 family of mitogen-activated protein kinases includes p38alpha (SAPK2a, CSBP), p38beta (SAPK2b), p38delta (SAPK4), and p38gamma (SAPK3/ERK6). p38alpha and p38beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p38delta isoform. In this review, we discuss the role of the p38alpha, p38beta, and p38gamma isoforms and then present recent findings that define a role for p38delta as a regulator of differentiation-dependent gene expression in keratinocytes.
引用
收藏
页码：823 / 828
页数：6
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