Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer

被引:3
|
作者
Hattori, Satomi [1 ]
Yoshikawa, Nobuhisa [1 ]
Mogi, Kazumasa [1 ]
Yoshida, Kosuke [1 ]
Yoshihara, Masato [1 ]
Tamauchi, Satoshi [1 ]
Ikeda, Yoshiki [1 ]
Yokoi, Akira [1 ]
Nishino, Kimihiro [1 ]
Niimi, Kaoru [1 ]
Suzuki, Shiro [2 ]
Kajiyama, Hiroaki [1 ]
机构
[1] Nagoya Univ, Grad Sch Med, Dept Obstet & Gynecol, Showa Ku, Tsurumai Cho, Nagoya, Aichi 4668550, Japan
[2] Aichi Canc Ctr Hosp, Dept Gynecol Oncol, Nagoya, Aichi 4640021, Japan
关键词
metastatic cervical cancer; tumor size; concurrent chemoradiotherapy; biomarker; prognosis; PROGRESSION-FREE SURVIVAL; QUALITY-OF-LIFE; PROGNOSTIC-FACTORS; PERFORMANCE STATUS; TUMOR SIZE; CARCINOMA; DISEASE; IMPACT;
D O I
10.3390/curroncol28030155
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
(1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to distant visceral organs with or without para-aortic lymph node metastasis (IVB) to identify primary tumor size and concurrent chemoradiotherapy. (3) Results: The overall survival (OS) for patients with a tumor >6.9 cm in size was significantly poorer than that for patients with a tumor <= 6.9 cm in the IVB group (p = 0.0028); the corresponding five-year OS rates in patients with a tumor <= 6.9 and >6.9 cm were 53.3% and 13.4%, respectively. In the multivariate analysis, tumor size and primary treatment were significantly associated with survival in metastatic cervical cancer. (4) Conclusions: Tumor size <= 6.9 cm and concurrent chemoradiotherapy as the primary treatment were favorable prognostic factors for patients with metastatic cervical cancer.
引用
收藏
页码:1663 / 1672
页数:10
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