Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety

被引：82
|
作者：
Ratkovic, Zoran [1 ]
Juranic, Zorica D. [2 ]
Stanojkovic, Tatjana [2 ]
Manojlovic, Dragan [3 ]
Vukicevic, Rastko D. [1 ]
Radulovic, Niko [4 ]
Joksovic, Milan D. [1 ]
机构：
[1] Univ Kragujevac, Fac Sci, Kragujevac 34000, Serbia
[2] Inst Oncol & Radiol Serbia, Belgrade 11000, Serbia
[3] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia
[4] Univ Nis, Dept Chem, Fac Sci & Math, Nish 18000, Serbia
来源：
BIOORGANIC CHEMISTRY | 2010年 / 38卷 / 1-3期
关键词：
Ferrocene; Chalcone analogues; Pyrazole; Cytotoxicity; RAPID COLORIMETRIC ASSAY; CELL-GROWTH; DERIVATIVES; LINES;
D O I：
10.1016/j.bioorg.2009.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：26 / 32
页数：7
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