Obtaining of high produce mutants of Actinoplanes teichomyceticus and optimization of fermentative medium

被引：0
|
作者：
Ukraintseva, SN [1 ]
Voinova, TM [1 ]
机构：
[1] All Russian Res Inst Phytopathol, Mol Biol Lab, Vyazemskii 143050, Moscow Region, Russia
来源：
BIOTECHNOLOGY AND MEDICINE | 2004年
关键词：
Actinoplanes; Teicoplanin; mutagenesis; biotest; strain improvement;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Teicoplanin, a glycopeptide antibiotic recently introduced in clinical practice, is produced by Actinoplanes teichomyceticus as a complex of several active substances [1]. The new antibiotic-producing strain A 27-2-4 with productivity at 10 times higher then initial strain ATCC 31121 of A. teichomyceticus was obtained using induced-mutagenesis. The activity of antibiotics in culture broth was determined by high-perfornance liquid chromatography and biotest. Size zone inhibition by biotest correlated with determined by HPLC concentration of antibiotic.
引用
收藏
页码：79 / 84
页数：6
相关论文
共 50 条
  • [1] Optimization of culture conditions and scale-up to plant scales for teicoplanin production by Actinoplanes teichomyceticus
    Hyung-Moo Jung
    Sang-Yong Kim
    Ponnandy Prabhu
    Hee-Jung Moon
    In-Won Kim
    Jung-Kul Lee
    Applied Microbiology and Biotechnology, 2008, 80
  • [2] Optimization of culture conditions and scale-up to plant scales for teicoplanin production by Actinoplanes teichomyceticus
    Jung, Hyung-Moo
    Kim, Sang-Yong
    Prabhu, Ponnandy
    Moon, Hee-Jung
    Kim, In-Won
    Lee, Jung-Kul
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 80 (01) : 21 - 27
  • [3] Cloning of metK from Actinoplanes teichomyceticus ATCC31121 and Effect of Its High Expression on Antibiotic Production
    Kim, Du-Yeong
    Hwang, Yong-II
    Choi, Sun-Uk
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 21 (12) : 1294 - 1298
  • [4] Isolation of γ-aminobutyric acid-producing bacteria and optimization of fermentative medium
    Lu, Xiaoxue
    Chen, Zhigang
    Gu, Zhenxin
    Han, Yongbin
    BIOCHEMICAL ENGINEERING JOURNAL, 2008, 41 (01) : 48 - 52
  • [5] Medium optimization for acarbose production by Actinoplanes sp A56 using the response surface methodology
    Wei, Sai-jin
    Cheng, Xin
    Huang, Lin
    Li, Kun-tai
    AFRICAN JOURNAL OF BIOTECHNOLOGY, 2010, 9 (13): : 1949 - 1954
  • [6] THE OBTAINING OF ASPERGILLUS-NIGER MUTANTS WITH HIGH PECTINOLYTIC ACTIVITY
    ILCZUK, Z
    FIEDUREK, J
    ZEITSCHRIFT FUR ALLGEMEINE MIKROBIOLOGIE, 1980, 20 (08): : 523 - 526
  • [7] MEDIUM OPTIMIZATION FOR THE FERMENTATIVE PRODUCTION OF GLUCOAMYLASE BY AN ISOLATED STRAIN PENICILLIUM-ITALICUM
    NANDI, R
    MUKHERJEE, SK
    JOURNAL OF MICROBIAL BIOTECHNOLOGY, 1988, 3 (02): : 15 - 21
  • [8] Application of statistical methodology to the optimization of fermentative medium for carotenoids production by Rhodobacter sphaeroides
    Chen, Deming
    Han, Yonbin
    Gu, Zhenxin
    PROCESS BIOCHEMISTRY, 2006, 41 (08) : 1773 - 1778
  • [9] OPTIMIZATION OF BASAL MEDIUM FOR FERMENTATIVE HYDROGEN PRODUCTION FROM CHEESE WHEY WASTEWATER
    Azbar, Nuri
    Dokgoz, F. Tuba Cetinkaya
    Peker, Zerife
    INTERNATIONAL JOURNAL OF GREEN ENERGY, 2009, 6 (04) : 371 - 380
  • [10] Combination of pre-fermentative and fermentative strategies to produce Malbec wines of lower alcohol and pH, with high chemical and sensory quality
    Fanzone, Martin L.
    Sari, Santiago E.
    Mestre, Maria, V
    Catania, Anibal A.
    Catelen, Maria J.
    Jofre, Viviana P.
    Gonzalez-Miret, Maria L.
    Combina, Mariana
    Vazquez, Fabio
    Maturano, Yolanda P.
    OENO ONE, 2020, 54 (04) : 1041 - 1058
12345