Transcriptional Control of a Plant Stem Cell Niche

被引：158

作者：

Busch, Wolfgang ^{[1
]}

Miotk, Andrej ^{[2
]}

Ariel, Federico D. ^{[5
]}

Zhao, Zhong ^{[2
]}

Forner, Joachim ^{[2
]}

Daum, Gabor ^{[2
]}

Suzaki, Takuya ^{[2
]}

Schuster, Christoph ^{[2
]}

Schultheiss, Sebastian J. ^{[1
]}

Leibfried, Andrea ^{[1
]}

Haubeiss, Silke ^{[1
]}

Ha, Nati ^{[2
,3
,4
]}

Chan, Raquel L. ^{[5
]}

Lohmann, Jan U. ^{[1
,2
]}

机构：

[1] Max Planck Inst Dev Biol, D-72076 Tubingen, Germany

[2] Heidelberg Univ, Heidelberg Inst Zool, Dept Stem Cell Biol, D-69120 Heidelberg, Germany

[3] Heidelberg Univ, CellNetworks Cluster Excellence, D-69120 Heidelberg, Germany

[4] Heidelberg Univ, BIOQUANT Ctr, D-69120 Heidelberg, Germany

[5] Univ Nacl Litoral, Inst Agrobiotecnol Litoral, Lab Biotecnol Vegetal, Santa Fe, Argentina

来源：

DEVELOPMENTAL CELL | 2010年 / 18卷 / 05期

关键词：

ARABIDOPSIS SHOOT MERISTEM; GENE-EXPRESSION MAP; DNA-BINDING; FLOWER DEVELOPMENT; CHROMATIN-IMMUNOPRECIPITATION; SUNFLOWER HOMEODOMAIN; RESPONSE REGULATORS; ESCHERICHIA-COLI; WUSCHEL; THALIANA;

D O I：

10.1016/j.devcel.2010.03.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of CLAVATA1, which is part of a negative feedback regulation of WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.

引用

页码：849 / 861

页数：13

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