In vivo multiphoton tomography of skin during wound healing and sear formation

被引：4
|
作者：
Riemann, Iris [1 ]
Ehlers, Alexander [1 ]
LeHarzic, Ronan [2 ]
Martin, Sven [2 ]
Reif, Annette [3 ]
Koenig, Karsten [1 ]
机构：
[1] Fraunhofer Inst Biomed Technol, IBMT, Ensheimer Str 48, D-66386 Ingbert, Germany
[2] JenLab GmbH, D-07745 Jena, Germany
[3] Univ Jena, D-07743 Jena, Germany
来源：
MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES VII | 2007年 / 6442卷
关键词：
multiphoton; NIR; laser; optical tomography; wound healing; SHG;
D O I：
10.1117/12.702407
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Multiphoton tomography based on femtosecond laser NIR (near infrared) pulses was used to perform non-invasive optical sectioning of skin with high spatial and intracellular resolution. Scar formation due to formation of collagen fibers is an important aspect during wound healing processes in skin and tissues and was monitored in vivo using the system DermaInspect. Multiphoton tomography was performed of a dermal wound after nevi extraction. The healing process and the aggregation of collagen fibers could be long term monitored due to the autofluorescence of endogenous fluorophores and SHG of collagen. The system DermaInspect might become a high resolution diagnostic tool for dermatological diagnostics and monitoring therapeutic effects.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Examination of wound healing after curettage by multiphoton tomography of human skin in vivo
    Springer, S.
    Zieger, M.
    Boettcher, A.
    Lademann, J.
    Kaatz, M.
    SKIN RESEARCH AND TECHNOLOGY, 2017, 23 (04) : 452 - 458
  • [2] Monitoring Wound Healing by Multiphoton Tomography/Endoscopy
    Koenig, Karsten
    Weinigel, Martin
    Bueckle, Rainer
    Kaatz, Martin
    Hipler, Christina
    Zens, Katharina
    Schneider, Stefan
    Huck, Volker
    PHOTONIC THERAPEUTICS AND DIAGNOSTICS XI, 2015, 9303
  • [3] In vivo multiphoton tomography of skin cancer
    Koenig, K.
    MELANOMA RESEARCH, 2016, 26 : E116 - E117
  • [4] In vivo multiphoton tomography of skin cancer
    Koenig, Karsten
    Riemann, Iris
    Ehlers, Alexander
    Bueckle, Rainer
    Dimitrow, Enrico
    Kaatz, Martin
    Fluhr, Joachim
    Elsner, Peter
    MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES VI, 2006, 6089
  • [5] Optimization of the measurement procedure during multiphoton tomography of human skin in vivo
    Springer, S.
    Zieger, M.
    Koenig, K.
    Kaatz, M.
    Lademann, J.
    Darvin, M. E.
    SKIN RESEARCH AND TECHNOLOGY, 2016, 22 (03) : 356 - 362
  • [6] In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing
    Jake D. Jones
    Hallie E. Ramser
    Alan E. Woessner
    Kyle P. Quinn
    Communications Biology, 1
  • [7] In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing
    Jones, Jake D.
    Ramser, Hallie E.
    Woessner, Alan E.
    Quinn, Kyle P.
    COMMUNICATIONS BIOLOGY, 2018, 1
  • [8] In vivo multiphoton tomography (MPT) of skin cancer
    Konig, K.
    Balu, M.
    Zachary, C.
    Harris, R.
    Krasieva, T.
    Tromberg, B.
    Kelly, K.
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2016, 14 : 37 - 38
  • [9] Non-invasive in vivo characterization of skin wound healing using label-free multiphoton microscopy
    Jones, Jake D.
    Majid, Fariah
    Ramser, Hallie
    Quinn, Kyle P.
    PHOTONICS IN DERMATOLOGY AND PLASTIC SURGERY, 2017, 10037
  • [10] Towards in vivo breast skin characterization using multiphoton tomography
    Batista, Ana
    Uchugonova, Aisada
    Breunig, Hans Georg
    Koenig, Karsten
    MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES XVII, 2017, 10069
12345