Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics

被引：60

作者：

Zielinsky, P. ^{[1
]}

Piccoli, A. L., Jr. ^{[1
]}

Manica, J. L. ^{[1
]}

Nicoloso, L. H. ^{[1
]}

Menezes, H. ^{[2
,3
]}

Busato, A. ^{[1
]}

Moraes, M. R. ^{[1
]}

Silva, J. ^{[1
]}

Bender, L. ^{[1
]}

Pizzato, P. ^{[1
]}

Aita, L. ^{[1
]}

Alievi, M. ^{[4
]}

Vian, I. ^{[5
]}

Almeida, L. ^{[5
]}

机构：

[1] FUC, IC, Fetal Cardiol Unit, BR-90620001 Porto Alegre, RS, Brazil

[2] FUC, IC, Postgrad Program, BR-90620001 Porto Alegre, RS, Brazil

[3] FUC, IC, Anim Expt Lab, BR-90620001 Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Sch Vet, Porto Alegre, RS, Brazil

[5] FUC, IC, Nutr Serv, BR-90620001 Porto Alegre, RS, Brazil

来源：

JOURNAL OF PERINATOLOGY | 2010年 / 30卷 / 01期

关键词：

echocardiography; ductus arteriosus; prostaglandins; PERSISTENT PULMONARY-HYPERTENSION; ADVANCING GESTATIONAL-AGE; GREEN TEA; RED WINE; INDOMETHACIN TOCOLYSIS; NONALCOHOLIC EXTRACT; CONSTRICTION; RATS; QUESTIONNAIRE; REPERFUSION;

D O I：

10.1038/jp.2009.101

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To test the hypothesis that maternal consumption of polyphenol-rich foods during third trimester interferes with fetal ductal dynamics by inhibition of prostaglandin synthesis. Study Design: In a prospective analysis, Doppler ductal velocities and right-to-left ventricular dimensions ratio of 102 fetuses exposed to polyphenol-rich foods (daily estimated maternal consumption >75th percentile, or 1089 mg) were compared with 41 unexposed fetuses (flavonoid ingestion <25th percentile, or 127 mg). Result: In the exposed fetuses, ductal velocities were higher (systolic: 0.96 +/- 0.23 m/s; diastolic: 0.17 +/- 0.05 m/s) and right-to-left ventricular ratio was higher (1.23 +/- 0.23) than in unexposed fetuses (systolic: 0.61 +/- 0.18 m/s, P<0.001; diastolic: 0.11 +/- 0.04 m/s, P = 0.011; right-to-left ventricular ratio: 0.94 +/- 0.14, P<0.001). Conclusion: As maternal polyphenol-rich foods intake in late gestation may trigger alterations in fetal ductal dynamics, changes in perinatal dietary orientation are warranted. Journal of Perinatology (2010) 30, 17-21; doi: 10.1038/jp.2009.101; published online 30 July 2009

引用

页码：17 / 21

页数：5

共 25 条

[1] Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
A O Galão
M C O Wender
J G L Ramos
Journal of Perinatology, 2010, 30 : 301 - 301
[2] Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
P Zielinsky
A L Piccoli
J L Manica
L H Nicoloso
H Menezes
A Busato
M R Moraes
J Silva
L Bender
P Pizzato
L Aita
M Alievi
I Vian
L Almeida
Journal of Perinatology, 2010, 30 : 17 - 21
[3] Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
Galao, A. O.
Wender, M. C. O.
Ramos, J. G. L.
JOURNAL OF PERINATOLOGY, 2010, 30 (04) : 301 - 301
[4] Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics Response
Zielinsky, P.
JOURNAL OF PERINATOLOGY, 2010, 30 (04) : 302 - 302
[5] Prenatal Effects of Maternal Consumption of Polyphenol-Rich Foods in Late Pregnancy upon Fetal Ductus Arteriosus
Zielinsky, Paulo
Busato, Stefano
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 2013, 99 (04) : 256 - 274
[6] EXPERIMENTAL CONSTRICTION OF FETAL DUCTUS ARTERIOSUS, OXIDATIVE STRESS, AND POLYPHENOL EXCRETION AFTER MATERNAL POLYPHENOL-RICH DIET IN LATE PREGNANCY
Zielinsky, Paulo
Bubols, Guilherme
Nicoloso, Luiz H.
Piccoli, Antonio, Jr.
Vian, Izabele
Moro, Angela
Charao, Mariele
Brucker, Natalia
Bulcao, Rachel
Nascimento, Sabrina
Goeethel, Gabriela
Alievi, Marcelo
Markoski, Melissa
Garcia, Solange
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (12) : A513 - A513
[7] New insights on fetal ductal constriction: role of maternal ingestion of polyphenol-rich foods
Zielinsky, Paulo
Piccoli, Antonio Luiz, Jr.
Langer Manica, Joao Luiz
Soares Nicoloso, Luiz Henrique
EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2010, 8 (02) : 291 - 298
[8] Fetal ductal arteriosus flow velocities and right ventricular size are influenced by maternal ingestion of polyphenol-rich common beverages
Zielinsky, P.
Manica, J.
Piccoli, A., Jr.
Nicoloso, L.
Frajndlich, R.
Menezes, H.
Busato, A.
Behrens, T.
Huber, J.
Silva, M.
CIRCULATION, 2008, 118 (12) : E468 - E468
[9] Deleterious effects of maternal ingestion of cocoa upon fetal ductus arteriosus in late pregnancy
Zielinsky, Paulo
Martignoni, Felipe V.
Vian, Izabele
FRONTIERS IN PHARMACOLOGY, 2014, 5
[10] Reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods: an open clinical trial
Zielinsky, P.
Piccoli, A. L., Jr.
Manica, J. L. L.
Nicoloso, L. H.
Vian, I.
Bender, L.
Pizzato, P.
Pizzato, M.
Swarowsky, F.
Barbisan, C.
Mello, A.
Garcia, S. C.
JOURNAL OF PERINATOLOGY, 2012, 32 (08) : 574 - 579

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