NMR-based metabolomics of biofluids in cancer

被引：27
|
作者：
Giskeodegard, Guro F. [1 ]
Madssen, Torfinn S. [1 ]
Euceda, Leslie R. [1 ]
Tessem, May-Britt [1 ]
Moestue, Siver A. [2 ,3 ]
Bathen, Tone F. [1 ]
机构：
[1] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, Trondheim, Norway
[2] Norwegian Univ Sci & Technol NTNU, Dept Clin & Mol Med, Trondheim, Norway
[3] Nord Univ, Dept Hlth Sci, Bodo, Norway
来源：
NMR IN BIOMEDICINE | 2019年 / 32卷 / 10期
基金：
欧洲研究理事会;
关键词：
biomarker; diagnosis; metabolism; monitoring; serum; urine; NUCLEAR-MAGNETIC-RESONANCE; EARLY BREAST-CANCER; PROSTATE-SPECIFIC ANTIGEN; HUMAN SEMINAL FLUID; PANCREATIC-CANCER; COLORECTAL-CANCER; BLADDER-CANCER; SERUM METABOLOMICS; INCREASED RISK; LUNG-CANCER;
D O I：
10.1002/nbm.3927
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
This review describes the current status of NMR-based metabolomics of biofluids with respect to cancer risk assessment, detection, disease characterization, prognosis, and treatment monitoring. While the metabolism of cancer cells is altered compared with that of non-proliferating cells, the metabolome of blood and urine reflects the entire organism. We conclude that many studies show impressive associations between biofluid metabolomics and cancer progression, but translation to clinical practice is currently hindered by lack of validation, difficulties in biological interpretation, and non-standardized analytical procedures.
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页数：12
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