Association of six SNPs in SLC7A7 with glioma risk in a Chinese population

Glioma is the most common type of tumors in the central nervous system. We performed a case-control study in a Chinese population, and investigated the contributions of six SNPs (rs12433985, rs12888930, rs7151065, rs12436190, rs12884337 and rs2065134) of SLC7A7 to the susceptibility to glioma. We selected 159 patients with histological confirmed glioma and 319 healthy control subjects between March 2013 and March 2015. Genotyping of SLC7A7 rs12433985, rs12888930, rs7151065, rs12436190, rs12884337 and rs2065134 was carried out in a 384-well plate format on the sequenom MassARRAY platform. We observed that the AG and AA genotypes of rs12433985 were associated with a higher risk of developing glioma in comparison to those harboring the GG genotype, and the adjusted ORs (95% CI) was 1.59 (1.02-2.48) and 1.98 (1.12-3.50), respectively. The CC genotypes of rs12888930 had 2.29 fold risk of developing glioma when compared with the TT genotype (adjusted OR=2.29, 95% CI=1.33-3.94). The SLC7A7 rs12888930 polymorphism had correlation with radiation exposure (Trend of X-2=4.84, P=0.03). The T-G-G-G-T-C and T-A-G-G-T-T haplotypes showed an increased risk in glioma risk, and the ORs (95% CI) were 6.74 (2.63-17.25) and 5.37 (1.89-15.30), respectively; while the T-G-G-G-T-T haplotype was associated with a reduced risk in glioma (OR=0.41; 95% CI=0.25-0.67; P < 0.001). In summary, we observed that the SLC7A7 rs12433985 and rs12888930 genetic mutations ere significantly correlated with an elevated risk of developing glioma, and the development of glioma risk could be affected by the SLC7A7 haplotype differences.