Clipping the Wings of Glioblastoma: Modulation of WNT as a Novel Therapeutic Strategy

被引：32
|
作者：
Suwala, Abigail K. [1 ]
Hanaford, Allison [2 ]
Kahlert, Ulf D. [1 ]
Maciaczyk, Jaroslaw [1 ]
机构：
[1] Univ Med Ctr Dusseldorf, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany
[2] Johns Hopkins Univ Hosp, Dept Pathol, Div Neuropathol, Baltimore, MD 21287 USA
来源：
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2016年 / 75卷 / 05期
关键词：
Glioma; Inhibitors; Noncanonical WNT signaling; Prognostic markers; Small molecules; WNT; SMALL-MOLECULE INHIBITOR; GLIOMA STEM-CELLS; BETA-CATENIN; SIGNALING PATHWAY; MESENCHYMAL TRANSITION; SELF-RENEWAL; NEURONAL DIFFERENTIATION; NUCLEAR-LOCALIZATION; PHASE-II; PROMOTES;
D O I：
10.1093/jnen/nlw013
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Glioblastoma (GBM) is the most malignant brain tumor and has a dismal prognosis. Aberrant WNT signaling is known to promote glioma cell growth and dissemination and resistance to conventional radio- and chemotherapy. Moreover, a population of cancer stem-like cells that promote glioma growth and recurrence are strongly dependent on WNT signaling. Here, we discuss the role and mechanisms of aberrant canonical and noncanonical WNT signaling in GBM. We present current clinical approaches aimed at modulating WNT activity and evaluate their clinical perspective as a novel treatment option for GBM.
引用
收藏
页码：388 / 396
页数：9
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