Pd(gly-L-his-L-lys)Cl: solution structure and ternary complex formation with mono-and tetranucleotides

被引：11

作者：

Rombeck, I ^{[1
]}

Lippert, B ^{[1
]}

机构：

[1] Univ Dortmund, Fachbereich Chem, Lehrstuhl Anorgan Chem 3, D-44221 Dortmund, Germany

来源：

INORGANICA CHIMICA ACTA | 1998年 / 273卷 / 1-2期

关键词：

NMR spectroscopy; palladium complexes; ternary complexes; glycylhistidyllysine complexes; tripeptide complexes; oligonucleotide complexes;

D O I：

10.1016/S0020-1693(97)06011-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The tripeptide complex Pd(gly-L-his-L-lys)Cl (Pd(GHK)Cl, 1) has been studied by a variety of NMR techniques (H-1, H-1 E.COSY, H-1 NOESY, H-1,C-13 HMQC), by ESI-MS, as well as simulated annealing and molecular dynamics methods. Reactions of 1 with isolated 5'-deoxynucleotides of guanine, cytidine, adenine and thymine, alone and in competition, have been carried out in water and followed by H-1 NMR spectroscopy. They reveal preferential binding of Pd(GHK)(+) to guanine N7 in weakly to moderately acidic solution and slow rotation of the Pd tripeptide entity about the metal-N7 bond below 276 K. The self-complementary tetranucleotide 5'-d(GTAC) reacts with 1 in D2O, pD 3.5, at guanine N7. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：31 / 40

页数：10

共 22 条

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