Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis

被引：8
|
作者：
Shalapour, Shabnam [1 ,2 ]
Karin, Michael [1 ,2 ]
机构：
[1] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, 9500 Gilman Dr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pathol, 9500 Gilman Dr, La Jolla, CA 92093 USA
来源：
CELL METABOLISM | 2016年 / 23卷 / 05期
关键词：
CANCER; TUMORIGENESIS; HEPATOCYTES; MICE;
D O I：
10.1016/j.cmet.2016.04.018
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A new study has added loss of CD4(+) T cells caused by aberrant lipid metabolism to the list of mechanisms promoting nonalcoholic steatohepatitis progression to liver cancer (Ma et al., 2016). Exposure of CD4(+) T cells to free linoleic acid causes their ROS-mediated depletion, thereby favoring liver cancer growth.
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页码：759 / 761
页数：4
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