Co-administration of citalopram and clozapine: effect on plasma clozapine levels

被引：23
|
作者：
Taylor, D [1 ]
Ellison, Z [1 ]
Shaw, LE [1 ]
Wickham, H [1 ]
Murray, R [1 ]
机构：
[1] Bethlem & Maudsley NHS Trust, London SE5 8AZ, England
来源：
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1998年 / 13卷 / 01期
关键词：
clozapine; citalopram; cytochromes p4501A2/2D6; interaction;
D O I：
10.1097/00004850-199801000-00003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Antidepressants are frequently used in the treatment of depressive symptoms associated with schizophrenia. In patients taking clozapine, choice of antidepressant is complicated by additive pharmacodynamic effects and by pharmacokinetic interactions. We predicted that citalopram would not elevate plasma clozapine levels when the two drugs were co-administered because it does not inhibit the relevant enzyme systems. In this preliminary study of five patients given citalopram and clozapine there was no overall change in mean clozapine levels. Based on this limited evidence, citalopram might be the antidepressant of choice in patients taking clozapine. (C) 1998 Rapid Science Ltd.
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收藏
页码：19 / 21
页数：3
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