DUAL INHIBITION OF PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) AND mTOR AS A NEW THERAPEUTIC OPTION FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL)

被引：0
|
作者：
Chiarini, F. [1 ]
Grimaldi, C. [1 ]
Tazzari, P. L. [2 ]
Ricci, F. [2 ]
Pagliaro, P. [2 ]
Martelli, A. M. [1 ]
机构：
[1] Univ Bologna, Dipartimento Sci Anat Umane, I-40126 Bologna, Italy
[2] St Orsola Marcello Malpighi Hosp, Bologna, Italy
来源：
CYTOMETRY PART A | 2010年 / 77A卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：167 / 167
页数：1
相关论文
共 50 条
  • [1] PI3K/Akt/mTOR signaling in T-cell acute lymphoblastic leukemia (T-ALL): A new option for targeted therapy
    Martelli, Alberto M.
    Evangelisti, Camilla
    Bertagnin, Daniela
    McCubrey, James A.
    Chiarini, Francesca
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2011, 28 : S14 - S14
  • [2] Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia
    Chiarini, Francesca
    Fala, Federica
    Tazzari, Pier Luigi
    Ricci, Francesca
    Astolfi, Annalisa
    Pession, Andrea
    Pagliaro, Pasqualepaolo
    McCubrey, James A.
    Martelli, Alberto M.
    CANCER RESEARCH, 2009, 69 (08) : 3520 - 3528
  • [3] The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL)
    Gazi, Mohiuddin
    Moharram, Sausan A.
    Marhall, Alissa
    Kazi, Julhash U.
    CANCER LETTERS, 2017, 392 : 9 - 16
  • [4] Dual Inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin with NVP-BEZ235 as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia.
    Chiarini, Francesca
    Grimaldi, Cecilia
    Ricci, Francesca
    Tazzari, Pierluigi
    Evangelisti, Camilla
    Pession, Andrea
    Pagliaro, Pasqualepaolo
    McCubrey, James
    Martelli, Alberto M.
    BLOOD, 2009, 114 (22) : 799 - 800
  • [5] Improving nelarabine efficacy in refractory/relapsed T-cell acute lymphoblastic leukemia (T-ALL) by targeting aberrant PI3K/mTOR signaling
    Chiarini, F.
    Cappellini, A.
    Lonetti, A.
    Bertaina, A.
    Locatelli, F.
    Melchionda, F.
    Pession, A.
    Martelli, A. M.
    EUROPEAN JOURNAL OF CANCER, 2016, 61 : S133 - S133
  • [6] INHIBITION OF CLASS I PHOSPHATIDYLINOSITOL 3-KINASES (PI3KS) ISOFORMS IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL): WHICH IS THE BEST THERAPEUTIC STRATEGY?
    Lonetti, A.
    Cappellini, A.
    Sparta, A.
    Bressanin, D.
    Francesca, B.
    Francesca, C.
    Evangelisti, C.
    Orsini, E.
    Martelli, A.
    HAEMATOLOGICA, 2014, 99 : 274 - 274
  • [7] Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL)
    Arjmand, Fateme
    Shojaei, Samaneh
    Khalili, Mitra
    Dinmohammadi, Hossein
    Poopak, Behzad
    Mohammadi-Yeganeh, Samira
    Mortazavi, Yousef
    BIOIMPACTS, 2024, 14 (04)
  • [8] PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic Leukemia Cells: A New Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia.
    Chiarini, Francesca
    Fala, Federica
    Ricci, Francesca
    Tazzari, PierLuigi
    Astolfi, Annalisa
    Pession, Andrea
    McCubrey, James
    Martelli, Alberto M.
    BLOOD, 2008, 112 (11) : 671 - 671
  • [9] PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia
    Silveira, Andre Bortolini
    Albertoni Laranjeira, Angelo Brunelli
    Libanio Rodrigues, Gisele Olinto
    Leal, Paulo Cesar
    Cardoso, Bruno Antonio
    Barata, Joao Taborda
    Yunes, Rosendo Augusto
    Tonin Zanchin, Nilson Ivo
    Brandalise, Silvia Regina
    Yunes, Jose Andres
    ONCOTARGET, 2015, 6 (15) : 13105 - 13118
  • [10] Targeting Wnt/β-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia
    Evangelisti, Cecilia
    Chiarini, Francesca
    Cappellini, Alessandra
    Paganelli, Francesca
    Fini, Milena
    Santi, Spartaco
    Martelli, Alberto M.
    Neri, Luca M.
    Evangelisti, Camilla
    JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (06) : 5413 - 5428
12345