Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

被引：13
|
作者：
Daengrot, Charuwan [1 ,2 ]
Rukachaisirikul, Vatcharin [1 ,2 ]
Tadpetch, Kwanruthai [1 ,2 ]
Phongpaichit, Souwalak [3 ,4 ]
Bowornwiriyapan, Kawitsara [3 ,4 ]
Sakayaroj, Jariya [5 ]
Shen, Xu [6 ]
机构：
[1] Prince Songkla Univ, Dept Chem, Hat Yai 90112, Thailand
[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Thailand
[3] Prince Songkla Univ, Nat Prod Res Ctr Excellence, Hat Yai 90112, Thailand
[4] Prince Songkla Univ, Dept Microbiol, Fac Sci, Hat Yai 90112, Thailand
[5] Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk, Khlong Luang 12120, Pathum Thani, Thailand
[6] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 46期
关键词：
DIPHENYL ETHER DERIVATIVES; XANTHONE DERIVATIVES; METABOLITES; BIOSYNTHESIS; BENZOPHENONE; PURPUROGENUM; AZAPHILONE; INHIBITORS; YO-2;
D O I：
10.1039/c6ra04401h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new xanthone (penicillanthone, 1) and three new diphenyl ether derivatives (penicillidic acids A-C, 2-4) together with 14 known compounds (5-18) were isolated from the soil-derived fungus Penicillium aculeatum PSU-RSPG105. The structures were elucidated by spectroscopic analyses. The absolute configuration of compound 1 was determined using the Snatzke's method whereas those of compounds 2-4 was established by comparison of their optical rotations with those of structurally related compounds. Compound 5 exhibited mild antimycobacterial activity against Mycobacterium tuberculosis with an MIC value of 25 mu g mL (1) and was noncytotoxic to noncancerous Vero cells. In addition, altenusin (12) displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 32 mu g mL(-1) and mild activity towards Vero cells with an IC50 value of 19.46 mu M.
引用
收藏
页码：39700 / 39709
页数：10
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