Skeletal-Related Events in Patients with Metastatic Renal Cell Carcinoma: A Systematic Review

被引:1
|
作者
Jang, Albert [1 ]
Chen, Shuang R. [1 ]
Xie, John [1 ]
Bilen, Mehmet A. [2 ,3 ]
Barata, Pedro C. [1 ,4 ]
机构
[1] Tulane Univ, Dept Med, Sch Med, New Orleans, LA 70112 USA
[2] Emory Univ, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
[3] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA
[4] Tulane Canc Ctr, New Orleans, LA USA
关键词
Skeletal-related events; metastatic renal cell carcinoma; bone metastases; skeletal metastases; pathological fracture; bone-directed targeted therapies; BONE-TARGETED THERAPY; ZOLEDRONIC ACID; PROSTATE-CANCER; RADIOFREQUENCY ABLATION; PREOPERATIVE EVALUATION; PROGNOSTIC-SIGNIFICANCE; DECOMPRESSIVE SURGERY; OSSEOUS METASTASES; PILOT TRIAL; SURVIVAL;
D O I
10.3233/KCA-200087
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
About one-third of advanced renal cell carcinoma (RCC) patients have bone metastases, which subsequently leads to the development of skeletal-related events (SREs), broadly defined to include surgery and radiation to bone, bone pain, pathological fracture, spinal cord compression, or hypercalcemia. The cumulative impact of SREs in RCC has not been well studied. SREs increase morbidity and mortality of RCC patients, although many interventions do significantly reduce their rates of development and improve prognosis. We performed a systematic review from the existing literature in PubMed from January 2002 through September 2019 and summarized the body of evidence regarding the development, prevention, prognosis and treatment of SREs in advanced RCC patients.
引用
收藏
页码:93 / 102
页数:10
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