A comparison of donor lymphocyte infusions or imatinib mesylate for patients with chronic myelogenous leukemia who have relapsed after allogeneic stem cell transplantation

被引：0
|
作者：
Weisser, Martin [1 ,2 ]
Tischer, Johanna [1 ,2 ]
Schnittger, Susanne [3 ]
Schoch, Claudia [3 ]
Ledderose, Georg [1 ,2 ]
Kolb, Hans Jochem [1 ,2 ]
机构：
[1] Univ Munich, Hematopoet Cell Transplantat, Dept Med 3, Klinikum Grosshadern,Ludwig Maximilian Univ Munic, Munich, Germany
[2] GSF Natl Res Ctr Environm & Hlth, Munich, Germany
[3] Munich Leukemia Lab, Munich, Germany
来源：
HAEMATOLOGICA | 2006年 / 91卷 / 05期
关键词：
donor lymphocyte infusion; imatinib; chronic myelogenous leukemia; allogeneic stem cell transplantation; relapse;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Imatinib mesylate is highly effective in relapsed chronic myelogenous leukemia (CML) after allogeneic hematopoetic stem cell transplantation (HSCT). However, it is unknown whether imatinib produces durable molecular remissions. The outcome of CML patients transplanted at our center who had received only imatinib for relapse after HSCT was compared with that of patients treated with donor lymphocyte infusions (DLI). Imatinib therapy resulted in a higher incidence of relapse and inferior leukemia-free survival (p=0.006 and p=0.016, respectively). These data suggest that imatinib alone probably does not cure relapse after HSCT.
引用
收藏
页码：663 / 666
页数：4
相关论文
共 50 条
  • [1] RESPONSE TO COMBINED USE OF DONOR LYMPHOCYTE INFUSIONS AND IMATINIB MESYLATE IN PATIENTS RELAPSED AFTER ALLOGENEIC STEM CELL TRANSPLANTATION FOR CHRONIC MYELOID LEUKEMIA
    Bavaro, P.
    Pompetti, F.
    Olioso, P.
    Papatinetti, G.
    Santarone, S.
    Di Carlo, P.
    Di Bartolomeo, E.
    Di Bartolomeo, P.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 137 - 137
  • [2] Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia
    Kantarjian, HM
    O'Brien, S
    Cortes, JE
    Giralt, SA
    Rios, MB
    Shan, JQ
    Giles, FJ
    Thomas, DA
    Faderl, S
    De Lima, M
    Garcia-Manero, G
    Champlin, R
    Arlinghaus, R
    Talpaz, M
    [J]. BLOOD, 2002, 100 (05) : 1590 - 1595
  • [3] Allogeneic stem cell transplantation and donor lymphocyte infusions for chronic myelomonocytic leukemia
    M A Elliott
    A Tefferi
    W J Hogan
    L Letendre
    D A Gastineau
    S M Ansell
    A Dispenzieri
    M A Gertz
    S R Hayman
    D J Inwards
    M Q Lacy
    I N Micallef
    L F Porrata
    M R Litzow
    [J]. Bone Marrow Transplantation, 2006, 37 : 1003 - 1008
  • [4] Allogeneic stem cell transplantation and donor lymphocyte infusions for chronic myelomonocytic leukemia
    Elliott, M
    Tefferi, A
    Hogan, WJ
    Letendre, L
    Gastineau, DA
    Ansell, SM
    Dispenzieri, A
    Gertz, MA
    Hayman, SR
    Inwards, DJ
    Lacy, MQ
    Micallef, IN
    Porrata, LF
    Litzow, MR
    [J]. BONE MARROW TRANSPLANTATION, 2006, 37 (11) : 1003 - 1008
  • [5] Donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukaemia
    Gilleece, MH
    Dazzi, F
    [J]. LEUKEMIA & LYMPHOMA, 2003, 44 (01) : 23 - 28
  • [6] Imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in the accelerated phase
    Jiang, Qian
    Xu, Lan-Ping
    Liu, Dai-Hong
    Liu, Kai-Yan
    Chen, Shan-Shan
    Jiang, Bin
    Jiang, Hao
    Chen, Huan
    Chen, Yu-Hong
    Han, Wei
    Zhang, Xiao-Hui
    Wang, Yu
    Qin, Ya-Zhen
    Liu, Yan-Rong
    Lai, Yue-Yun
    Huang, Xiao-Jun
    [J]. BLOOD, 2011, 117 (11) : 3032 - 3040
  • [7] Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia
    Dazzi, F
    Szydlo, RM
    Cross, NCP
    Craddock, C
    Kaeda, J
    Kanfer, E
    Cwynarski, K
    Olavarria, E
    Yong, A
    Apperley, JF
    Goldman, JM
    [J]. BLOOD, 2000, 96 (08) : 2712 - 2716
  • [8] Donor lymphocyte infusions in patients with leukemia after allogeneic hematopoietic stem cell transplantation.
    Liu, QF
    Sun, J
    Liu, YL
    Zhou, SY
    [J]. BLOOD, 2002, 100 (11) : 448B - 448B
  • [9] Late response to donor lymphocyte infusions in patients with chronic myeloid leukemia relapsing after allogeneic stem cell transplantation
    Gómez, M
    Urbano-Ispizua, A
    Cervantes, F
    Fernández-Avilés, F
    Rovira, M
    Carreras, E
    [J]. HAEMATOLOGICA, 2002, 87 (09) : 1003 - 1005
  • [10] Donor lymphocyte infusions for relapse of chronic myelogenous leukemia after reduced intensity conditioning stem cell transplantation
    Basak, G. W.
    van Biezen, A.
    Brand, R.
    Szydlo, R.
    Schattenberg, A.
    Von Dem Borne, P. A.
    Kroger, N.
    Verdonck, L.
    Finke, J.
    Bunjes, D.
    Guglielmi, C.
    Wiktor-Jedrzejczak, W.
    Olavarria, E.
    de Witte, T.
    [J]. BONE MARROW TRANSPLANTATION, 2010, 45 : S240 - S240
12345