1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults

被引：10

作者：

Kara, Firat ^{[1
]}

Joers, James M. ^{[2
]}

Deelchand, Dinesh K. ^{[2
]}

Park, Young Woo ^{[2
]}

Przybelski, Scott A. ^{[3
]}

Lesnick, Timothy G. ^{[3
]}

Senjem, Matthew L. ^{[1
,4
]}

Zeydan, Burcu ^{[1
,5
]}

Knopman, David S. ^{[5
]}

Lowe, Val J. ^{[1
]}

Vemuri, Prashanthi ^{[1
]}

Mielke, Michelle M. ^{[3
,5
]}

Machulda, Mary M. ^{[6
]}

Jack, Clifford R. ^{[1
]}

Petersen, Ronald C. ^{[5
]}

Oz, Gulin ^{[2
]}

Kantarci, Kejal ^{[1
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN USA

[2] Univ Minnesota, Dept Radiol, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

[3] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA

[4] Mayo Clin, Dept Informat Technol, Rochester, MN USA

[5] Mayo Clin Minnesota, Dept Neurol, Rochester, MN USA

[6] Mayo Clin Minnesota, Dept Psychiat & Psychol, Rochester, MN USA

来源：

NEUROBIOLOGY OF AGING | 2022年 / 112卷

关键词：

Proton magnetic resonance spectroscopy; Sex differences; Tau; Amyloid-beta; Positron emission tomography; Glutamate; N-acetylaspartate; MAGNETIC-RESONANCE-SPECTROSCOPY; POSTERIOR CINGULATE CORTEX; ALZHEIMERS-DISEASE; SHORT-ECHO; NEUROCHEMICAL PROFILES; AMYLOID DEPOSITION; APOE EPSILON-4; BRAIN; GLUTAMATE; IMPAIRMENT;

D O I：

10.1016/j.neurobiolaging.2021.12.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Proton magnetic resonance spectroscopy (H-1 MRS) may provide information on pathophysiological changes associated with tau deposition in cognitively unimpaired older adults. In this study, the associations of posterior cingulate gyrus tau and amyloid beta (A beta) deposition on PET with H-1 MRS metabolite ratios acquired from bilateral posterior cingulate gyri were investigated in cognitively unimpaired older adults. Participants (n = 40) from the Mayo Clinic Study of Aging underwent single-voxel sLASER H-1 MRS from the posterior cingulate gyrus at 3 Tesla, F-18-flortaucipir, and C-11-Pittsburgh Compound B (PiB) PET. An increase in posterior cingulate gyrus tau deposition, but not elevated A beta, was associated with lower N-acetylaspartate/total creatine (tCr) and glutamate (Glu)/tCr ratios, and sex by tau interaction was ob-served in association with Glu/tCr. Higher tau levels in cognitively unimpaired older adults are associated with biomarkers of neural and synaptic injury even in the absence of cognitive impairment and these relationships appear to be stronger in women than in men. (C) 2022 Elsevier Inc. All rights reserved.

引用

页码：16 / 26

页数：11

共 17 条

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