Hematopoiesis and the bacterial microbiome

被引：63

作者：

Yan, Hannah ^{[1
,2
]}

Baldridge, Megan T. ^{[3
]}

King, Katherine Y. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Sect Infect Dis, Houston, TX 77030 USA

[2] Baylor Coll Med, Grad Sch Biomed Sci, Program Immunol, Houston, TX 77030 USA

[3] Washington Univ, Sch Med, Dept Internal Med, Div Infect Dis,Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA

来源：

BLOOD | 2018年 / 132卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PARENTERAL ANTIMICROBIAL THERAPY; STEM-CELL TRANSPLANTATION; INFLAMMATORY-BOWEL-DISEASE; HUMAN GUT; INTESTINAL MICROBIOTA; MURINE HEMATOPOIESIS; ULCERATIVE-COLITIS; ANTIBIOTIC-THERAPY; BONE-MARROW; NEUTROPENIA;

D O I：

10.1182/blood-2018-02-832519

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.

引用

页码：559 / 564

页数：6

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