Role of Prostaglandin E2 in the Progression of Gastrointestinal Cancer

被引：14
|
作者：
Wilson, David Jay [1 ]
DuBois, Raymond N. [2 ]
机构：
[1] Med Univ South Carolina, Coll Med, Charleston, SC USA
[2] Med Univ South Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA
来源：
CANCER PREVENTION RESEARCH | 2022年 / 15卷 / 06期
关键词：
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GASTRIC-CANCER; COLORECTAL-CANCER; CYCLOOXYGENASE-2; EXPRESSION; ESOPHAGEAL CANCER; RANDOMIZED-TRIAL; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE; COX-2; INHIBITOR; CELL EXPANSION; ASPIRIN USE;
D O I：
10.1158/1940-6207.CAPR-22-0038
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chronic inflammation is a well-established risk factor for several diseases, including cancer. It influences tumor cell biology and the type and density of immune cells in the tumor microenvironment (TME), promoting cancer development. While proinflammatory cytokines and chemokines modulate cancer development, emerging evidence has shown that prostaglandin E-2 (PGE(2)) is a known mediator connecting chronic inflammation to cancerization. This review highlights recent advances in our understanding of how the elevation of PGE(2) production promotes gastrointestinal cancer initiation, progression, invasion, metastasis, and recurrence, including modulation of immune checkpoint signaling and the type and density of immune cells in the tumor/tissue microenvironment.
引用
收藏
页码：355 / 364
页数：10
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