Ca-release channels (ryanodine receptors) of sarcoplasmic reticulum: Structure and properties. A review

被引:0
|
作者
Rubtsov, AM [1 ]
Batrukova, MA [1 ]
机构
[1] Moscow MV Lomonosov State Univ, Sch Biol, Dept Biochem, Moscow 119899, Russia
关键词
sarcoplasmic reticulum; Ca-release channels; ryanodine receptors; excitation-contraction coupling;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent data on characteristics of the structure, function, and regulation of sarcoplasmic reticulum Ca-release channels (ryanodine receptors) From various types of muscles are summarized. The history of identification and purification of Ca-release ch;channels, the properties of isoforms expressed in various tissues, their electric characteristics, and regulation bl endogenous and exogenous compounds are described. The phosphorylation of Ca-release channels by protein kinases and their interaction with various intracellular regulatory proteins are discussed. The proposed mechanisms of excitation-contraction coupling and the role of the Ca-release channels in this process are analyzed.
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页码:933 / 945
页数:13
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