The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

被引：641
|
作者：
Guillou, Herve [2 ]
Zadravec, Damir [1 ]
Martin, Pascal G. P. [2 ]
Jacobsson, Anders [1 ]
机构：
[1] Stockholm Univ, Arrhenius Lab F3, Wenner Gren Inst, Dept Physiol, SE-10691 Stockholm, Sweden
[2] INRA, UR66, Lab Pharmacol & Toxicol, F-31931 Toulouse, France
来源：
PROGRESS IN LIPID RESEARCH | 2010年 / 49卷 / 02期
关键词：
Elongase; Desaturase; VLCFA; PUFA; Knockout mice; STEAROYL-COA DESATURASE-1; COENZYME-A DESATURASE; BROWN ADIPOSE-TISSUE; PERMEABILITY BARRIER FUNCTION; ELEMENT-BINDING PROTEIN-1; ACTIVATED RECEPTOR-ALPHA; CHAIN ELONGATION SYSTEM; INDUCED GENE-EXPRESSION; CYTOCHROME B(5) DOMAIN; RAT-LIVER;
D O I：
10.1016/j.plipres.2009.12.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In mammalian cells, elongases and desaturases play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In the past decade, a great deal has been learnt about these enzymes and the first part of this review summarizes our current knowledge concerning these enzymes. More recently, several transgenic mouse models lacking either an elongase (Elovl3(-/-), Elovl4(-/-), Elovl5(-/-), Elovl6(-/-)) or a desaturase (Scd-1(-/-), Scd-2(-/-), Fads2(-/-)) have been developed and the second part of this review focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：186 / 199
页数：14
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