Treatment of Pediculosis Capitis: A Critical Appraisal of the Current Literature

被引:24
|
作者
Feldmeier, Hermann [1 ]
机构
[1] Charite, Inst Microbiol & Hyg, D-12203 Berlin, Germany
关键词
HUMAN HEAD LICE; HUMANUS-CAPITIS; PYRETHROID RESISTANCE; BARTONELLA-QUINTANA; LOUSE INFESTATION; IVERMECTIN LOTION; ORAL IVERMECTIN; CLINICAL-TRIALS; PERMETHRIN; EFFICACY;
D O I
10.1007/s40257-014-0094-4
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Pediculosis capitis is the most common ectoparasitic disease in children in industrialized countries and extremely common in resource-poor communities of the developing world. The extensive use of pediculicides with a neurotoxic mode of action has led to the development and spread of resistant head lice populations all over the world. This triggered the development of compounds with other modes of action. The current literature on treatment approaches of head lice infestation was searched, and published randomized controlled trials were critically analyzed. The following compounds/family of compounds were identified: spinosad, a novel compound with a new neurotoxic mode of action, isopropyl myristate, 1,2-octanediol, ivermectin, plant-based products, and dimeticones. The efficacy and safety of these compounds are reviewed and recommendations for the treatment of pediculosis capitis in individuals as well as the interruption of ongoing epidemics are provided.
引用
收藏
页码:401 / 412
页数:12
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