Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells

被引：0
|
作者：
Martin, JHJ [1 ]
Symonds, A [1 ]
Chohan, S [1 ]
机构：
[1] Wolverhampton Univ, Sch Appl Sci, Div Biol Sci, Wolverhampton WV1 1SB, England
来源：
ONCOLOGY REPORTS | 2003年 / 10卷 / 04期
关键词：
breast cancer; nitric oxide; droloxifene; toremifene;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.
引用
收藏
页码：979 / 984
页数：6
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