Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide

被引：76

作者：

Mossa, JS

El-Feraly, FS

Muhammad, I ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] King Saud Univ, Coll Pharm, Dept Pharmacol, Riyadh 11451, Saudi Arabia

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 11期

关键词：

antimycobacterial constituents; isonicotinic acid hydrazide; atypical mycobacteria; synergism; Mycobacterium tuberculosis H37Rv;

D O I：

10.1002/ptr.1420

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synergistic activity of antimycobacterial constituents from Saudi plants was evaluated in combination with isonicotinic acid hydrazide (INH) against four atypical organisms, namely, Mycobacterium intracellulare, M. smegmatis, M. xenopei and M. chelonei. The potency of INH was increased four-fold, using an in vitro checkerboard method, against each mycobacteria when tested with a subtoxic concentration of the totarol, isolated from J. procera. The MIC values of totarol, ferulenol (from Ferula communis) and plumbagin (from Plumbago zeylanica) were thus lowered from 1.25-2.5 to 0.15-0.3 mug/mL due to synergism with INH. When tested against the resistant strain of M. tuberculosis H37Rv, plumbagin and 7beta-hydroxyabieta-8,13-dien-11,12-dione exhibited inhibitory activity at <12.5 mug/mL, while others were inactive at this concentration. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：934 / 937

页数：4