Natural and designer binding sites made by phage display technology

被引：161
|
作者：
Hoogenboom, HR
Chames, P
机构：
[1] Target Quest BV, NL-6202 AZ Maastricht, Netherlands
[2] Maastricht Univ, Dept Pathol, NL-6202 AZ Maastricht, Netherlands
[3] Univ Hosp Maastricht, NL-6202 AZ Maastricht, Netherlands
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 08期
关键词：
D O I：
10.1016/S0167-5699(00)01667-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the past decade, the drive to develop completely human antibodies for human therapy has led to the development of phage display technology. This technology is able to deliver the ultimate in antibody engineering, that is, high-affinity fully human antibodies to any antigen of choice. Here, this application of phage display technology is reviewed, and the many other antibody-engineering avenues this technology offers are highlighted.
引用
收藏
页码：371 / 378
页数：8
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