Evaluation of Sustained-Release Steroid Hydrogels in a Guinea Pig Model for Noise-Induced Hearing Loss

被引：11
|
作者：
Zhu, Chengjing [1 ]
Gausterer, Julia Clara [2 ]
Schoepper, Hanna [3 ]
Nieratschker, Michael [1 ]
Saidov, Nodir [1 ]
Ahmadi, Navid [1 ]
Honeder, Clemens [1 ]
Gabor, Franz [2 ]
Arnoldner, Christoph [1 ]
机构：
[1] Med Univ Vienna, Dept Otorhinolaryngol, Waehringer Guertel 18-20, AT-1090 Vienna, Austria
[2] Univ Vienna, Dept Pharmaceut Technol & Biopharmaceut, Vienna, Austria
[3] Univ Vet Med Vienna, Dept Pathobiol, Inst Anat Histol & Embryol, Vienna, Austria
来源：
AUDIOLOGY AND NEURO-OTOLOGY | 2018年 / 23卷 / 02期
基金：
奥地利科学基金会;
关键词：
Intratympanic glucocorticoids; Noise-induced hearing loss; Dexamethasone; Triamcinolone acetonide; Poloxamer; 407; OFFERS EFFECTIVE PROTECTION; INNER-EAR FUNCTION; INTRATYMPANIC INJECTION; TRIAMCINOLONE ACETONIDE; COCHLEAR IMPLANTATION; MENIERES-DISEASE; CONTROLLED-TRIAL; ACOUSTIC TRAUMA; IMPULSE NOISE; DOUBLE-BLIND;
D O I：
10.1159/000487662
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
The otoprotective effects of thermoreversible poloxamer 407 hydrogels containing dexamethasone or triamcinolone acetonide were evaluated in an animal model of noise-induced hearing loss. Seven days after noise exposure, hearing threshold shifts at 16 kHz were significantly reduced in the 6% dexamethasone group (p < 0.05). Even though no significant differences in hair cell counts were found, histological analysis revealed a significantly higher spiral ganglion cell density in the first turn of the cochlea in this group (p < 0.05). No otoprotective effects were observed after the application of the triamcinolone acetonide hydrogels. As the findings of this study indicate potential otoprotective effects of sustained topical dexamethasone delivery in the setting of noise-induced hearing loss, this strategy merits further evaluation. (C) 2018 S. Karger AG, Basel
引用
收藏
页码：73 / 81
页数：9
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