An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin

被引：17
|
作者：
Kinoshita, H
Taniguchi, T
Nishiguchi, M
Ouchi, H
Minami, T
Utsumi, T
Motomura, H
Tsuda, T
Ohta, T
Aoki, S
Komeda, M
Kamamoto, T
Kubota, A
Fuke, C
Arao, T
Miyazaki, T
Hishida, S
机构：
[1] Hyogo Med Univ, Dept Legal Med, Nishinomiya, Hyogo 6638501, Japan
[2] Hyogo Med Univ, Dept Ophthalmol, Nishinomiya, Hyogo 6638501, Japan
[3] Hyogo Prefectural Police Headquarters, Forens Sci Lab, Chuo Ku, Kobe, Hyogo 6508510, Japan
[4] Hyogo Med Univ, Dept Surg Pathol, Nishinomiya, Hyogo 6638501, Japan
[5] Univ Ryukyus, Dept Legal Med, Nishihara, Okinawa 9030215, Japan
来源：
FORENSIC SCIENCE INTERNATIONAL | 2003年 / 133卷 / 1-2期
关键词：
verapamil; metoprolol; digoxin; poisoning; drug interaction;
D O I：
10.1016/S0379-0738(03)00056-2
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
We present here a fatal poisoning case involving verapamil, metoprolol and digoxin. A 39-year-old male was found dead in his room, and a lot of empty packets of prescribed drugs were found near the corpse. The blood concentrations of verapamil, metoprolol and digoxin were 9.2 mug/ml, 3.6 mug/ml and 3.2 ng/ml, respectively. The cause of death was given as cardiac failure, bypotension and bradycardia due to a mixed drug overdose of verapamil, metoprolol and digoxin, based on the results of the autopsy and toxicological examination. We speculate that the toxicity of verapamil is potentiated by drug interaction with metoprolol and digoxin. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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页码：107 / 112
页数：6
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