Microwave-Assisted Synthesis of Nitro-Substituted Tetrahydropyridoazepines

被引：5
|
作者：
Schultz, Thomas [1 ]
Turner, Sean C. [1 ]
Braje, Wilfried M. [1 ]
机构：
[1] Abbott GmbH & Co KG, D-67061 Ludwigshafen, Germany
来源：
SYNTHESIS-STUTTGART | 2010年 / 08期
关键词：
ketones; condensation; regioselectivity; heterocycles; pyridines; DIELS-ALDER REACTIONS; ORGANIC-SYNTHESIS; HETEROCYCLES; DERIVATIVES;
D O I：
10.1055/s-0029-1218678
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The microwave-assisted condensation of azepan-4-ones with 3,5-dinitro-1-methylpyridin-2-one in the presence of ammonia was found to be a highly efficient method for the synthesis of nitro-substituted tetrahydropyridoazepines. Variation of the substituent at the amino group enables the regioselective synthesis of tetrahydropyrido[3,2-c]azepines and tetrahydropyrido[2,3-d]azepines.
引用
收藏
页码：1339 / 1343
页数：5
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