Aripiprazole acts as a selective dopamine D2 receptor partial agonist

被引：60
|
作者：
Wood, Martyn [1 ]
Reavill, Charlie [1 ]
机构：
[1] GlaxoSmithKline Schizophrenia & Bipolar Neurophys, Psychiat CEDD, Harlow CM19 5AW, Essex, England
来源：
EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2007年 / 16卷 / 06期
关键词：
D O I：
10.1517/13543784.16.6.771
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aripiprazole has made a significant contribution to the treatment of schizophrenia and related disorders with an improved safety and tolerability profile, which has been attributed to its unique pharmacological profile. It has been claimed that partial agonism of the dopamine D-2 and 5-HT1A receptors and antagonism of the 5-HT2 receptor contribute to the clinical profile of aripiprazole, a so-called dopamine- and 5-HT stabiliser. However, recent studies have questioned the role of the 5-HT-mediated systems in the mechanism of action of aripiprazole. This report reviews published and unpublished data that suggest that aripiprazole acts as a selective partial agonist at the dopamine D, receptor and does not affect 5-HT receptors at therapeutic doses.
引用
收藏
页码：771 / 775
页数：5
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