Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges

被引：17
|
作者：
Chang, Yun Sil [1 ]
Ahn, So Yoon [1 ]
Sung, Sein [1 ]
Park, Won Soon [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, 81 Irwon Ro, Seoul 06351, South Korea
来源：
YONSEI MEDICAL JOURNAL | 2017年 / 58卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
Mesenchymal stem cells; bronchopulmonary dysplasia; intraventricular hemorrhage; hypoxic ischemic encephalopathy; newborn; UMBILICAL-CORD BLOOD; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; MESENCHYMAL STROMAL CELLS; HYPEROXIC LUNG INJURY; BIRTH-WEIGHT INFANTS; VERSUS-HOST-DISEASE; BONE-MARROW; BRONCHOPULMONARY DYSPLASIA; ADIPOSE-TISSUE; INTRAVENTRICULAR HEMORRHAGE;
D O I：
10.3349/ymj.2017.58.2.266
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhage in preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.
引用
收藏
页码：266 / 271
页数：6
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