Regio- and enantioselective carbolithiation of non-activated C=C bonds

被引：22
|
作者：
Norsikian, S [1 ]
Baudry, M [1 ]
Normant, JF [1 ]
机构：
[1] Univ Paris 06, Associe CNRS, Lab Chim Organo Elements, F-75252 Paris 05, France
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 34期
关键词：
carbometalation; (-)-sparteine; enantioselection;
D O I：
10.1016/S0040-4039(00)01091-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Primary alkyllithiums in the presence of (-)-sparteine, add to terminal conjugated dienes. They also add to 2,4-pentadien-1-ols if they are substituted on C(5), and give rise to allyllithium intermediates, 2-Alkylalkan-1-ols have thus been prepared with ee's up to 74%. (C) 2000 Elsevier Science Ltd, All rights reserved.
引用
收藏
页码：6575 / 6578
页数：4
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