Palladium-catalyzed cyclization of 1,6-enyne with 2-bromoarylaldehyde: domino sequence to [5-7-6] tricyclic ring systems

被引：9
|
作者：
Fang, Xianjie
Tong, Xiaofeng [1 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 02期
关键词：
Palladium catalyst; Domino sequence; 1,6-Enyne; 5-7-6] Tricyclic ring; Intramolecular Aldol-condensation; BAYLIS-HILLMAN ADDUCTS; GUANACASTEPENE-A; ALLYLIC ALCOHOLS; UNSATURATED ALCOHOLS; FORMAL SYNTHESIS; CARBON SKELETON; ARYL BROMIDES; HECK REACTION; ARYLATION; HALIDES;
D O I：
10.1016/j.tetlet.2009.11.006
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A domino sequence of cyclization of 1,6-enyne with 2-bromoarylaldehyde followed by the intramolecular Aldol-condensation has been realized in the presence of 5 mol % of palladium catalyst. This sequence provides a convenient protocol to access polycyclic ring systems with readily available starting materials under simple Pd(0)-catalyzed conditions. The intramolecular Aldol-condensation has been proposed as the key step for the catalytic cycle. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：317 / 320
页数：4
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