CD34-positive uterine lipoleiomyoma in a postmenopausal woman with chronic glomerulonephritis

Lipoleiomyomas are rare benign mesenchymal tumors in the uterus that are composed of an admixture of smooth muscle and adipose tissue. Their pathogenesis is still controversial, although many theories have been proposed so far. Herein, the authors report the first case of a CD-34 positive lipoleiomyoma in a patient with chronic glomerulonephritis. A 60-year-old postmenopausal woman with chronic glomerulonephritis and hyperlipidemia underwent a screening ultrasonographic examination, and a mass located on the left side of the uterus was detected. She underwent hysterectomy and bilateral salpingo-oophorectomy. Pathologically, the tumor was composed of an admixture of smooth muscle cells and mature adipocytes. The diagnosis of lipoleiomyoma was made. Immunohistochemically, some smooth muscle cells in the tumor were positive for CD34, which is one of the mesenchymal stem cell markers. The significance of CD34 positivity remains obscure. Further studies are needed to clarify the role of CD34-positive cells in the pathogenesis of lipoleiomyomas.