Radical alkylation of C(sp3)-H bonds with diacyl peroxides under catalyst-free conditions

Herein, we describe a protocol for alkylation reactions of C(sp(3))-H bonds with diacyl peroxides by means of a process involving cross-coupling between an alkyl radical and an alpha-aminoalkyl radical. The mild, catalyst- and additive-free conditions make this protocol superior to previously reported C(sp(3))-H alkylation strategies. The protocol was applied to 1,2,3,4-tetrahydroisoquinolines and a tetrahydro-beta-carboline derivative and could be carried out on a gram scale, indicating its utility for the alkylation of late-stage synthetic intermediates.