Synthesis and biological evaluation of novel N-substituted benzamides as anti-migration agents for treatment of osteosarcoma

被引：3
|
作者：
Chen, Xiaojing [1 ]
Wang, Guangbao [1 ]
Alsayed, Ali Mohammed Mohammed [1 ]
Du, Zongxuan [1 ]
Liu, Lu [1 ]
Ma, Yue [1 ]
Liu, Peng [1 ]
Zhang, Qianwen [1 ]
Chen, Xianxin [1 ]
Chen, Wenbin [1 ]
Ye, Faqing [2 ]
Zheng, Xiaohui [1 ]
Liu, Zhiguo [1 ]
机构：
[1] Wenzhou Med Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, 1210 Univ Town, Wenzhou 325035, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Sch Pharmaceut Sci, 1210 Univ Town, Wenzhou 325035, Zhejiang, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 214卷
关键词：
N-substituted benzamides; Osteosarcoma; Anti-migration; Activity;
D O I：
10.1016/j.ejmech.2021.113203
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of novel N-substituted (indole or indazole) benzamides were synthesized, and their antitumor properties were evaluated. The majority of tested compounds possessed moderate cytotoxicity, but inspiringly, we verified that active compound 5d presents an astonishing advantage by inhibiting the adhesion, migration, and invasion of osteosarcoma (OS) cells in vitro. Mechanistically, we confirmed 5d inhibited the migration ability of OS cells via the expression of genes related to adhesion, migration, and invasion. This effects of 5d suggest that it can be used as a potential chemotherapeutic drug to some aggressive and/or metastatic cancers, as well as in combination with other clinical anti-cancer drugs. In turn, this could enhance the therapeutic effect or reduce the risk of cell migration. (C) 2021 Elsevier Masson SAS. All rights reserved.
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页数：19
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