Complement and complement inhibitors: their role in autoimmune and inflammatory diseases

被引:5
|
作者
Sheerin, NS [1 ]
Sacks, SH [1 ]
机构
[1] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Dept Nephrol & Transplantat, London SE1 9RT, England
来源
关键词
D O I
10.1097/00041552-199805000-00011
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The role of complement in the pathogenesis of renal injury is now being confirmed with the use of knockout technology and specific inhibitors. Chronic injury, particularly of the tubules and interstitium, and local complement synthesis are emerging as potential additional targets for complement-based therapy. Strategies are being developed to prevent complement-induced injury both in transplant and in native kidneys. (C) 1998 Rapid Science Ltd.
引用
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页码:305 / 310
页数:6
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