Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

被引：45
|
作者：
Soligo, D
Ibatici, A
Berti, E
Morandi, P
Longhi, E
Venegoni, L
Corbellino, M
Annaloro, C
Robbiolo, L
Della Volpe, A
Alessi, E
Deliliers, GL
机构：
[1] Osped Maggiore Milano, IRCCS, Ctr Trapianti Midollo, Dept Hematol, I-20122 Milan, Italy
[2] Osped Maggiore Milano, IRCCS, Dept Dermatol, I-20122 Milan, Italy
[3] Osped Maggiore Milano, IRCCS, Transplantat Immunol & Blood Transfus Serv, I-20122 Milan, Italy
[4] Univ Milan, Inst Infect & Trop Dis, Milan, Italy
来源：
BONE MARROW TRANSPLANTATION | 2003年 / 31卷 / 08期
关键词：
mycosis fungoides; nonmyeloablative regimen; allogeneic stem cell transplantation;
D O I：
10.1038/sj.bmt.1703872
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
引用
收藏
页码：663 / 666
页数：4
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