Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

被引：27

作者：

Allegra, Alessandro ^{[1
]}

Spatari, Giovanna ^{[2
]}

Mattioli, Stefano ^{[3
]}

Curti, Stefania ^{[3
]}

Innao, Vanessa ^{[1
]}

Ettari, Roberta ^{[4
]}

Allegra, Andrea Gaetano ^{[1
]}

Giorgianni, Concetto ^{[2
]}

Gangemi, Sebastiano ^{[5
]}

Musolino, Caterina ^{[1
]}

机构：

[1] Univ Messina, Dept Human Pathol Adulthood & Childhood, Div Hematol, I-98122 Messina, Italy

[2] Univ Messina, Dept Environm Sci Safety Terr Food & Hlth, I-98122 Messina, Italy

[3] Univ Bologna, Dept Med & Surg Sci DIMEC, I-40126 Bologna, Italy

[4] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, I-98122 Messina, Italy

[5] Univ Hosp G Martino, Sch & Div Allergy & Clin Immunol, Dept Clin & Expt Med, Via Consolare Valeria SNC, I-98125 Messina, Italy

来源：

MEDICINA-LITHUANIA | 2019年 / 55卷 / 10期

关键词：

formaldehyde; acute myeloid leukemia; occupational exposure; cancer; carcinogenesis; LYMPHOHEMATOPOIETIC MALIGNANCIES; WORKERS; HEMATOTOXICITY; MORTALITY; CELLS; RISK;

D O I：

10.3390/medicina55100638

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and objective: The aim of the present study was to evaluate associations between cumulative and peak formaldehyde exposure and occurrence of acute myeloid leukemia. Material and Methods: A comprehensive search was performed using the PubMed and Embase databases. We included studies presenting information about the role of formaldehyde in leukemic occurrence and mortality risk. Then, full texts of the selected references were assessed, and references of included studies were checked to identify additional articles. Result: The information was then summarized and organized in the present review. A total of 81 articles were obtained from the search. Conclusion: Findings from the review of the literature do not support the hypothesis that formaldehyde is a cause of acute myeloid leukemia.

引用

页数：9

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