The effect of marker heterozygosity on the power to detect linkage disequilibrium

被引：0
|
作者：
Ott, J
Rabinowitz, D
机构：
[1] COLUMBIA UNIV,DEPT STAT,NEW YORK,NY 10027
[2] ROCKEFELLER UNIV,LAB STAT GENET,NEW YORK,NY 10021
来源：
GENETICS | 1997年 / 147卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study. The analysis suggests that, despite the penalties for multiple testing incurred with multiple alleles, greater heterozygosity results in greater power. The results of the simulation study are in accord with those of the analysis.
引用
收藏
页码：927 / 930
页数：4
相关论文
共 50 条
  • [1] The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations
    Sham, PC
    Zhao, JH
    Curtis, D
    ANNALS OF HUMAN GENETICS, 2000, 64 : 161 - 169
  • [2] Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations
    Nielsen, DM
    Ehm, MG
    Zaykin, DV
    Weir, BS
    GENETICS, 2004, 168 (02) : 1029 - 1040
  • [3] The power to detect linkage disequilibrium with quantitative traits in selected samples
    Abecasis, GR
    Cookson, WOC
    Cardon, LR
    AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (06) : 1463 - 1474
  • [4] LINKAGE DISEQUILIBRIUM AND HETEROZYGOSITY AT THE CD4 LOCUS
    TISHKOFF, SA
    KIDD, KK
    CYTOGENETICS AND CELL GENETICS, 1994, 67 (04): : 274 - 275
  • [5] TRANSMISSION DISEQUILIBRIUM TEST (TDT) FOR LINKAGE AND LINKAGE DISEQUILIBRIUM BETWEEN DISEASE AND MARKER
    SPIELMAN, RS
    EWENS, WJ
    AMERICAN JOURNAL OF HUMAN GENETICS, 1993, 53 (03) : 863 - 863
  • [6] The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker
    Yang, XQ
    Huang, J
    Logue, MW
    Vieland, VJ
    HUMAN HEREDITY, 2005, 59 (04) : 210 - 219
  • [7] Marker to marker linkage disequilibrium in commercial chicken breeding populations
    Heifetz, E. M.
    Fulton, J. E.
    O'Sullivan, N.
    Zhao, H.
    Dekkers, J. C. M.
    Soller, M.
    JOURNAL OF ANIMAL SCIENCE, 2005, 83 : 45 - 45
  • [8] The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity
    Holland, Dominic
    Frei, Oleksandr
    Desikan, Rahul
    Fan, Chun-Chieh
    Shadrin, Alexey A.
    Smeland, Olav B.
    Andreassen, Ole A.
    Dale, Anders M.
    GENETICS, 2021, 217 (03)
  • [9] Evaluation Of Power For Linkage Disequilibrium Mapping
    Yamada, Ryo
    Terao, Chikashi
    Kawaguchi, Takahisa
    Narahara, Maiko
    GENETIC EPIDEMIOLOGY, 2012, 36 (02) : 168 - 168
  • [10] The effect of linkage disequilibrium on multipoint linkage analysis
    Levinson, DF
    Potash, JB
    Knowles, JA
    Crowe, RR
    DePaulo, JR
    Scheftner, WA
    Weissman, MM
    Holmans, P
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 138B (01) : 143 - 143
12345