Synthesis and biological evaluation of 1-azabicyclo[3.2.1]octanes: new dopamine transporter inhibitors

被引：5

作者：

Tamiz, AP

Smith, MP

Enyedy, I

Flippen-Anderson, J

Zhang, M

Johnson, KM

Kozikowski, AP

机构：

[1] Georgetown Univ, Med Ctr, Dept Neurol, Drug Discovery Program, Washington, DC 20007 USA

[2] Zebra Pharmaceut, Cambridge, MA 02142 USA

[3] USN, Struct Matter Lab, Res Lab, Washington, DC 20275 USA

[4] Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(00)00308-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1681 / 1686

页数：6

共 50 条

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