Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems

被引:58
|
作者
Siwaszek, Aleksandra [1 ,2 ]
Ukleja, Marta [1 ,2 ,3 ]
Dziembowski, Andrzej [1 ,2 ]
机构
[1] Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland
[2] Univ Warsaw, Fac Biol, Dept Genet & Biotechnol, Warsaw, Poland
[3] CSIC, CNB, Dept Struct Macromol, Madrid, Spain
关键词
Arabidopsis thaliana; Drosophila melanogaster; human; mRNA decay; mRNA surveillance; Saccharomyces cerevisiae; Schizosaccharomyces pombe; NONSENSE-MEDIATED DECAY; TRANSLATIONAL TERMINATION CODON; QUALITY-CONTROL PATHWAYS; P-BODY FORMATION; NO-GO DECAY; SACCHAROMYCES-CEREVISIAE; SCHIZOSACCHAROMYCES-POMBE; CCR4-NOT COMPLEX; DECAPPING ENZYME; FISSION YEAST;
D O I
10.4161/rna.34406
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The process of mRNA decay and surveillance is considered to be one of the main posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of stable, protein-coding transcripts is normally initiated by removal of the poly(A) tail followed by 5'-cap hydrolysis and degradation of the remaining mRNA body by Xrn1. Alternatively, the exosome complex degrades mRNA in the 3'>5'direction. The newly discovered uridinylation-dependent pathway, which is present in many different organisms, also seems to play a role in bulk mRNA degradation. Simultaneously, to avoid the synthesis of incorrect proteins, special cellular machinery is responsible for the removal of faulty transcripts via nonsense-mediated, no-go, non-stop or non-functional 18S rRNA decay. This review is focused on the major eukaryotic cytoplasmic mRNA degradation pathways showing many similarities and pointing out main differences between the main model-species: yeast, Drosophila, plants and mammals.
引用
收藏
页码:1122 / 1136
页数:15
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