Innovative Tools and Strategies for Optimizing Yeast Cell Factories

被引：39

作者：

Guirimand, Gregory ^{[1
,2
]}

Kulagina, Natalja ^{[2
]}

Papon, Nicolas ^{[3
,4
]}

Hasunuma, Tomohisa ^{[1
,5
]}

Courdavault, Vincent ^{[2
]}

机构：

[1] Kobe Univ, Grad Sch Sci Technol & Innovat, Kobe, Hyogo, Japan

[2] Univ Tours, Biomol & Biotechnol Vegetales BBV, Equipe Accueil EA 2106, Tours, France

[3] Univ Angers, Grp Etud Interact Hote Pathogene GEIHP, EA 3142, Angers, France

[4] Univ Brest, Struct Federat Rech SFR 4208, Interact Cellulaires & Applicat Therapeut ICAT, Angers, France

[5] Kobe Univ, Engn Biol Res Ctr, Kobe, Hyogo, Japan

来源：

TRENDS IN BIOTECHNOLOGY | 2021年 / 39卷 / 05期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

DE-NOVO PRODUCTION; SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; CURRENT STATE; BIOSYNTHESIS; PATHWAY; DRUG; PROMOTERS; EVOLUTION; ACID;

D O I：

10.1016/j.tibtech.2020.08.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Metabolic engineering (ME) aims to develop efficient microbial cell factories that can produce a wide variety of valuable compounds, ideally at the highest yield and from various feedstocks. We summarize recent developments in ME methods for tailoring different yeast cell factories (YCFs). In particular, we highlight the most timely and cutting-edge molecular tools and strategies for biosynthetic pathway optimization (including genome-editing tools), combinatorial transcriptional and posttranscriptional engineering (cis/trans regulators), dynamic control of metabolic fluxes (e.g., rewiring of primary metabolism), and spatial reconfiguration of metabolic pathways. Finally, we discuss challenges and perspectives for adaptive laboratory evolution (ALE) of yeast to advance ME of microbial cell factories.

引用

页码：488 / 504

页数：17

共 50 条

[1] Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis
Lv, Yongkun
Marsafari, Monireh
Koffas, Mattheos
Zhou, Jingwen
Xu, Peng
[J]. ACS SYNTHETIC BIOLOGY, 2019, 8 (11): : 2514 - 2523
[2] Yeast cell factories on the horizon
Nielsen, Jens
[J]. SCIENCE, 2015, 349 (6252) : 1050 - 1051
[3] Advances in Flavonoid and Derivative Biosynthesis: Systematic Strategies for the Construction of Yeast Cell Factories
Wang, Jian
Chen, Cheng
Guo, Qi
Gu, Yang
Shi, Tian-Qiong
[J]. ACS SYNTHETIC BIOLOGY, 2024, 13 (09): : 2667 - 2683
[4] A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories
Fisher, Amanda K.
Freedman, Benjamin G.
Bevan, David R.
Senger, Ryan S.
[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2014, 11 (18): : 91 - 99
[5] Fructan Biosynthesis by Yeast Cell Factories
Ko, Hyunjun
Sung, Bong Hyun
Kim, Mi-Jin
Sohn, Jung-Hoon
Bae, Jung-Hoon
[J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2022, 32 (11) : 1373 - 1381
[6] Yeast cell factories for production of taxadiene
Gencer, Hulya Karaca
Krivoruchko, Anastasia
Nielsen, Jens
[J]. YEAST, 2015, 32 : S154 - S154
[7] Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production
Ko, Yoo-Sung
Kim, Je Woong
Lee, Jong An
Han, Taehee
Kim, Gi Bae
Park, Jeong Eum
Lee, Sang Yup
[J]. CHEMICAL SOCIETY REVIEWS, 2020, 49 (14) : 4615 - 4636
[8] Fluorescent reporter libraries as useful tools for optimizing microbial cell factories: a review of the current methods and applications
Delvigne, Frank
Pecheux, Helene
Tarayre, Cedric
[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2015, 3
[9] INNOVATIVE STRATEGIES AND TOOLS FOR COLLABORATION MANAGEMENT
Stetter, Ralf
[J]. JOURNAL OF INTEGRATED DESIGN & PROCESS SCIENCE, 2005, 9 (01) : 31 - 40
[10] Adaptation strategies to innovative changes in the light-industries factories
Taranova, E., V
[J]. SOTSIOLOGICHESKIE ISSLEDOVANIYA, 2008, (09): : 47 - 52

← 1 2 3 4 5 →