Activation of C-F bonds α to C-C multiple bonds

被引：125

作者：

Hamel, Jean-Denys ^{[1
]}

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, CCVC, PROTEO, 1045 Ave Med, Quebec City, PQ G1V 0A6, Canada

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 73期

基金：

加拿大自然科学与工程研究理事会;

关键词：

(Z)-FLUOROALKENE DIPEPTIDE ISOSTERES; FUNCTIONALIZED GEM-DIFLUOROALKENES; CARBON-FLUORINE BONDS; NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION; PALLADIUM-CATALYZED SUBSTITUTION; ORGANOCOPPER-MEDIATED REDUCTION; INTRAMOLECULAR REDOX REACTION; EFFICIENT SYNTHETIC METHOD; DONOR-ACCEPTOR SYSTEMS; TRIFLUOROMETHYL GROUP;

D O I：

10.1039/c8cc05108a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-F bond activation has drawn a lot of attention in the past, and the case of C(sp(3))-F bonds is particularly interesting as those are the strongest single bonds carbon makes with any other element. This Feature Article aims at highlighting our work and that of others on the successful approaches that led to the activation of such C-F bonds at benzylic, allylic, propargylic and allenylic positions, for both mono- and polyfluorides. We now hope that this will set ground for discussions, contribute to fostering new ideas, and thus help in pushing current frontiers further.

引用

页码：10224 / 10239

页数：16

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