Modeling brain development and diseases with human cerebral organoids

被引：12

作者：

Shi, Yingchao ^{[1
]}

Wu, Qian ^{[2
,5
]}

Wang, Xiaoqun ^{[1
,3
,4
,6
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Bioland Lab Guangzhou,State Key Lab Brain & Cogni, Inst Brain Intelligence Technol Shanghai,CAS Ctr, Beijing 100101, Peoples R China

[2] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[3] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China

[6] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2021年 / 66卷

基金：

中国国家自然科学基金;

关键词：

PLURIPOTENT STEM-CELLS; SELF-ORGANIZATION; IN-VITRO; CORTICAL DEVELOPMENT; PROGENITOR-CELL; HUMAN ES; DIFFERENTIATION; EVOLUTION; DYNAMICS; NEURONS;

D O I：

10.1016/j.conb.2020.09.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Understanding the mechanisms that underlie human brain development and neurological and neuropsychiatric disorders is one of the key topics of neurobiology. Because of the poor accessibility of human and non-human primate brain tissues, the current perception and understanding of human brain development have been mainly derived from studies of rodents. However, some human-specific features of neural development cannot be well characterized by these animal models. Thanks to the advances in stem cell technologies, brain organoids are being under rapid development, showing the promising applications in decoding the human brain development and uncovering the pathology of brain diseases. In this review, we mainly summarized the recent advances in the development of brain organoid technology and discussed the limitations, applications and future prospects of this promising field.

引用

页码：103 / 115

页数：13

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