Purpose - This paper analyses the growing importance of Knowledge Transfer in the globalising economy, especially in relation to the policy driver in a number of countries to transform their current economies into Knowledge Economies. It discusses the various implications that these processes have for government policy on higher education systems, and the role of universities in economic development. It draws upon examples from around the world. Design methodology/approach - An overview and conceptual paper based on observations and research experience. Findings - This paper points to the importance of the development of Knowledge Economies and the ways in which this trend has exposed university systems to a more direct involvement in globalisation processes. It offers examples of the different higher education strategies that have been adopted in relation to economic development in countries such as Singapore, Malaysia, China, the UK, and South Africa. It also explores the different internationalisation strategies of universities. It highlights the potentially crucial role that universities can play as key players in this process, given their core functions of knowledge generation and transfer through teaching, research and a close engagement with commercial organisations. Originality/value - This paper raises critical questions for national governments as to what higher education strategies they need to consider to maximise the role that universities can play in knowledge transfer and economic development. It also points to the parallel issues that universities need to address as to their core role in society and the extent to which they wish to engage with wider processes of internationalisation and globalisation.